An internal thermal sensor controlling temperature preference in Drosophila
Fumika N. Hamada1, Mark Rosenzweig1, Kyeongjin Kang1, Stefan R. Pulver1, Alfredo Ghezzi1, Timothy J. Jegla2 & Paul A. Garrity1
National Center for Behavioral Genomics, Volen Center for Complex Systems, Biology Department, Brandeis University MS-008, 415 South Street, Waltham, Massachusetts 02454, USA
Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
Correspondence to: Paul A. Garrity1 Correspondence and requests for materials should be addressed to P.A.G. (Email: pgarrity@brandeis.edu).
Animals from flies to humans are able to distinguish subtle gradations in temperature and show strong temperature preferences1, 2, 3, 4. Animals move to environments of optimal temperature and some manipulate the temperature of their surroundings, as humans do using clothing and shelter. Despite the ubiquitous influence of environmental temperature on animal behaviour, the neural circuits and strategies through which animals select a preferred temperature remain largely unknown. Here we identify a small set of warmth-activated anterior cell (AC) neurons located in the Drosophila brain, the function of which is critical for preferred temperature selection. AC neuron activation occurs just above the fly's preferred temperature and depends on dTrpA1, an ion channel that functions as a molecular sensor of warmth. Flies that selectively express dTrpA1 in the AC neurons select normal temperatures, whereas flies in which dTrpA1 function is reduced or eliminated choose warmer temperatures. This internal warmth-sensing pathway promotes avoidance of slightly elevated temperatures and acts together with a distinct pathway for cold avoidance to set the fly's preferred temperature. Thus, flies select a preferred temperature by using a thermal sensing pathway tuned to trigger avoidance of temperatures that deviate even slightly from the preferred temperature. This provides a potentially general strategy for robustly selecting a narrow temperature range optimal for survival.作者: yyfiregod 时间: 2009-2-1 15:33
人是水冷的...作者: superray 时间: 2009-2-1 16:00
鼻孔也有辅助风道的作用{titter:]作者: sq1046 时间: 2009-2-1 19:10
这个帖子强悍{lol:]{lol:]{lol:]作者: lws009 时间: 2009-2-1 19:42
好冷啊。。。作者: given11 时间: 2009-2-1 20:52
我来围观的。。。作者: 168SEASON 时间: 2009-2-1 22:17
感谢LZ分享,支持@~作者: wang1394 时间: 2009-2-2 14:17
自己顶一个作者: amon 时间: 2009-2-2 14:33
寒,越来越冷了............作者: chhqw 时间: 2009-2-2 14:36
一般情况风冷,也有时候水冷,比如下暴雨或者被LP泼冷水作者: wjwsy 时间: 2009-2-2 14:53
请转移到医学论坛作者: wang1394 时间: 2009-2-2 15:12
终于成为正式会员了,庆祝一下作者: release 时间: 2009-2-2 15:52
嘘嘘和便便都是热腾腾的啊.....这是主动的..作者: rokinn1976 时间: 2009-2-2 15:58
成年人大脑热功耗是60-70W,大概和E8xxx相当吧。作者: gerryho 时间: 2009-2-2 16:13
这帖子准火,强帖留名!作者: 闹市侠隐 时间: 2009-2-2 18:21
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这贴…… 只能说lz有才 为了活跃度作者: boris_lee 时间: 2009-2-4 11:44
人脑是液冷系统,冷却液的流速是自动控制的,这是常识作者: 起个名字好难 时间: 2009-2-4 12:07
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